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The peptide bond hydrolysis that occurs at elevated temperatures is irreversible, and while the solution may appear clear, binding affinity to GHRH receptors drops below therapeutic thresholds

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As therapy, BPC 157, (10 µg/kg, 10 ng/kg, per-orally, in drinking water until sacrifice, or alternatively, intraperitoneally, first application at 30 min after surgery, last at 24 h before sacrifice), evidently rescues rats with the duodenocolic fistulas, since very beginning